Management of Chemical and Biological Samples for Screening Applications
(Sprache: Englisch)
For the first time the working knowledge of large screening centers in the pharmaceutical and biotechnological field is tied together to produce an integrated view of sample management that spans the full spectrum of this emerging discipline.
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Produktinformationen zu „Management of Chemical and Biological Samples for Screening Applications “
For the first time the working knowledge of large screening centers in the pharmaceutical and biotechnological field is tied together to produce an integrated view of sample management that spans the full spectrum of this emerging discipline.
Klappentext zu „Management of Chemical and Biological Samples for Screening Applications “
Filling an obvious gap in the scientific literature, this practice-oriented reference is the first to tie together the working knowledge of largescreening centers in the pharmaceutical and biotechnological field. It spans the entire fi eld of this emerging discipline, from compoundacquisition to collection optimization for specific purposes, to technology and quality control. In so doing, it applies two decades of expertise gathered by several large pharmaceutical companies to current and future challenges in high-throughput screening. With its treatment of libraries of small molecules as well as biobanks containing biomolecules, microorganisms and tissue samples, this reference is universally applicable for any molecular scientist involved in a large screening program.
Inhaltsverzeichnis zu „Management of Chemical and Biological Samples for Screening Applications “
PREFACE INTRODUCTION TO SAMPLE MANAGEMENT GENERATING A HIGH-QUALITY COMPOUND COLLECTION Defining Current Screening Collections Design Criteria for Enriching a Compound Collection with Drug-Like Compounds Concluding Remarks ASSESSING COMPOUND QUALITY Introduction Process Quality and Analytical Quality in Compound Management IdentityPurity/Stability Concentration/Solubility Conclusions DELIVERING AND MAINTAINING QUALITY WITHIN COMPOUND MANAGEMENT Introduction What is Quality from a Compound Management Perspective? Storage and Delivery of Samples in Solution Intercepting Low Purity Storage and Delivery of Solids Automation Quality Control and Reliability High-Quality Data Management Conclusion OBTAINING AND MAINTAINING HIGH-QUALITY TISSUE SAMPLES: SCIENTIFIC AND TECHNICAL CONSIDERATIONS TO PROMOTE EVIDENCE-BASED BIOBANKING PRACTICE (EBBP) Introduction The Path toward Integration of Evidence-based Biobanking Practice Integrating Evidence-based Biobanking Practice into Sample Protocols Final Thoughts and Recommendations THINKING LEAN IN COMPOUND MANAGEMENT LABORATORIES The Emergence of 'Lean Thinking'The Application of 'Lean Thinking'Lean Thinking in Drug Discovery A Lean Laboratory Toolbox Streamlining Compound Processing - An Example Summary APPLICATION OF SUPPLY MANAGEMENT PRINCIPLES IN SAMPLE MANAGEMENT Introduction Common Pitfalls of Sample Management Sample Management and Supply Chain Concepts Implementing the Sample Management Strategy Sample Management OrganizationSample Management Informatics Avoid Monolithic Silos of Excellence Position and Synchronize Inventory Expand the Sample Management Boundary Measuring and Assessing Effectiveness and Quality Conclusions SOLID SAMPLE WEIGHING AND DISTRIBUTION The Practicalities and Technology of Weighing Solid Compounds Logistical Challenges of Transportation of Small Molecules MANAGING A GLOBAL BIOLOGICAL RESOURCE OF CELLS AND CELLULAR DERIVATIVES Introduction Diversity of Collections Sourcing and Acquisition
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Authentication and Characterization Cryopreservation, Storage, and Production Data Management Quality and Standards Order Fulfillment and Distribution Offsite Biorepository Management Regulatory and Legal Compliance Ownership and Intellectual Property Management Collaborations Conclusion DEVELOPMENT OF AUTOMATION IN SAMPLE MANAGEMENT Introduction Historical Background Automation of Sample Management Today System Building Blocks Storage Systems Liquid Handler Accessories Plate Handling, Integration Case Study: Evolution of a Compound Management Group Results APPLICATIONS OF ACOUSTIC TECHNOLOGY Introduction Compound-Handling Challenges in Drug Discovery Acoustic Drop Ejection - Performance, Quality Assurance, and Platform Validation Acoustic-Assisted Compound Solubilization and Mixing Acoustic Applications in Drug Discovery Emerging Applications ENHANCING BIOREPOSITORY SAMPLE INTEGRITY WITH AUTOMATED STORAGE AND RETRIEVAL The Emerging Growth of Biobanking Automated Storage and Retrieval in a Biorepository Configuration of an Automated Biorepository Conclusions INFORMATION TECHNOLOGY SYSTEMS FOR SAMPLE MANAGEMENT Sample Registration Intellectual Property and Laboratory Notebooks Some Observations on Information Technology Biological Data Management KEY FEATURES OF A COMPOUND MANAGEMENT SYSTEM Why Do We Need Compound Management Information Technology Systems? Compound Management Software Benefits of Commercially Available Compound Management SystemsWHAT DOES AN HTS FILE OF THE FUTURE LOOK LIKE? Introduction History of Compounds Collection for HTS Impact of High-Throughput Chemistry on Corporate Files Chemical Library Management The Concept of Drug-Likeness and the Lipinski Rules Quality versus Quantity The Emergence of the Subsets: Fragment, G-Protein-CoupledReceptor (GPCR), Ion Channel, Kinase, Protein-Protein Interaction, Chemogenomics, Library Of Pharmacologically Active Compounds (LOPAC), Central Nervous System (CNS), and Diversity Re-designing the Corporate File for the Future Future Routes for Hit Identification NEW ENABLING TECHNOLOGY Introduction A Drop-On-Demand Printer for Dry Powder Dispensing Piezo Dispense Pens: Integrated Storage and Dispensing Devices and their Potential in Secondary Screening and Diagnostic Manufacturing Future Directions in Acoustic Droplet Ejection Technology Closing Remarks THE IMPACT OF FUTURE TECHNOLOGIES WITHIN BIOBANKING Introduction The Role of Biobanks in Biomedical Research The Increasing Complexity of Biobanking Future Technologies and Biobanking: How Could New Technologies Affect the Daily Activities of Biobanks? The Future of Biobanking Does Not Depend on Technological Developments Alone Conclusions OUTSOURCING SAMPLE MANAGEMENT Outsourcing in the Pharmaceutical Industry Outsourcing Biological Specimen Collections Conclusions SAMPLE MANAGEMENT YESTERDAY AND TOMORROW The Role of Sample Management Automation of Compound Management Compound Integrity Reduction of RedundancyThe Future of Sample Management? Concluding Remarks
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Autoren-Porträt
Mark Wigglesworth manages the UK Lead Optimisation area of Sample Management Technologies for GlaxoSmithKline. Over the past 10 years Mark has managed large and small compound stores, assay ready plate production and compound set provision, as well as interacting with many areas of drug discovery. Additionally, he has led several drug discovery programmes and overseen multiple screening platforms providing structure activity relationship data within GlaxoSmithKline?s screening organisations.Now a freelance business consultant, Terry Wood retired in 2011 as the manager of the Liquid Store Centre of Emphasis at Pfizer's world-wide R&D department, based in Sandwich (UK). He has been involved in the high-throughput screening process for the whole of his 25 year career with Pfizer. This has given him a first hand and broad knowledge about the challenges and caveats of assay design, development and prosecution. His prime responsibility focused on the management of Pfizer's extensive compound file, using a range of automated systems for sample preparation, storage and delivery.nologies for GlaxoSmithKline. Over the past 10 years Mark has managed large and small compound stores, assay ready plate production and compound set provision, as well as interacting with many areas of drug discovery. Additionally, he has led several drug discovery programmes and overseen multiple screening platforms providing structure activity relationship data within GlaxoSmithKline?s screening organisations.
Now a freelance business consultant, Terry Wood retired in 2011 as the manager of the Liquid Store Centre of Emphasis at Pfizer's world-wide R&D department, based in Sandwich (UK). He has been involved in the high-throughput screening process for the whole of his 25 year career with Pfizer. This has given him a first hand and broad knowledge about the challenges and caveats of assay design, development and prosecution. His prime responsibility focused on the management of Pfizer's
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extensive compound file,
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Bibliographische Angaben
- 2012, XXVI, 406 Seiten, 11 farbige Abbildungen, 97 Schwarz-Weiß-Abbildungen, Maße: 17,5 x 24,7 cm, Gebunden, Englisch
- Herausgegeben: Mark Wigglesworth, Terry Wood
- Verlag: Wiley-VCH
- ISBN-10: 352732822X
- ISBN-13: 9783527328222
- Erscheinungsdatum: 20.03.2012
Sprache:
Englisch
Rezension zu „Management of Chemical and Biological Samples for Screening Applications “
"In the same vein, the chapters on new and enabling technologies, as well as how best to approach the options for outsourcing samples serve to provide a complete overview of all aspects of this discipline and complete the overall picture for the reader." ( ChemBioChem , 1 January 2013) "The book is a useful tool for any sample management organization, and will be particularly helpful as a guide for both updating the already existing structures and for planning future infrastructures dedicated to sample management." ( Annali , 2012)
Pressezitat
"In the same vein, the chapters on new and enabling technologies, as well as how best to approach the options for outsourcing samples serve to provide a complete overview of all aspects of this discipline and complete the overall picture for the reader." ( ChemBioChem , 1 January 2013)"The book is a useful tool for any sample management organization, and will be particularly helpful as a guide for both updating the already existing structures and for planning future infrastructures dedicated to sample management." ( Annali , 2012)
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