Metallopharmaceuticals I
DNA Interactions
(Sprache: Englisch)
With contributions by numerous experts
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Produktdetails
Produktinformationen zu „Metallopharmaceuticals I “
With contributions by numerous experts
Klappentext zu „Metallopharmaceuticals I “
Each volume provides the reader, whether engaged in chemistry, biochemistry, biology or molecular medicine, with a comprehensive summary and critical overview of a topic of great current interest written by leading international experts. Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magnetic resonsance imaging (e.g. Gd) demonstrates that the toxicity of metals can be finely controlled via the approriate choice of ligands. The successful targeting of radioisotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been used in medicine but only recently have advances been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics.
Inhaltsverzeichnis zu „Metallopharmaceuticals I “
Lippard, S.J.; Gelasco, A.: Anticancer activity of cisplatin and related complexes.- Barnhard, C.F.J.; Raynaud, F.I., Kelland, L.R.: Development of an orally-active platinum, anticancer drug: JM 216.- Natile, G.; Coluccia, M.: Trans-platinum compounds in cancer therapy: a largely unexplored strategy for identifying antitumor platinum drugs.- Farrell, N.J.: Dinuclear DNA Crosslinking Complexes.- Lippert, B.; Leng, M.: The Role of Metal Ions in Antisense and Antigene Strategies.- Sava, G.; Alessio, E.; Bergamo, A.; Mestroni, G.: Sulfoxide Ruthenium Complexes: Non-Toxic Tools for the Selective Treatment of Solid Tumor Metastases.- Keppler, B.K.; Borsky, K., Pieper, T.: Non-Platinum Antitumor Compounds.
Bibliographische Angaben
- 2010, XI, 200 Seiten, Maße: 15,5 x 23,5 cm, Kartoniert (TB), Englisch
- Herausgegeben: Michael J. Clarke, Peter J. Sadler
- Verlag: Springer, Berlin
- ISBN-10: 3642084400
- ISBN-13: 9783642084409
Sprache:
Englisch
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