Neisseria gonorrhoeae
Methods and Protocols
(Sprache: Englisch)
This detailed book addresses the continual development and application of new methods and protocols to understand the biology of the pathogen Neisseria gonorrhoeae. Beginning with gonococcus biology and antimicrobial resistance, the volume continues with...
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Klappentext zu „Neisseria gonorrhoeae “
This detailed book addresses the continual development and application of new methods and protocols to understand the biology of the pathogen Neisseria gonorrhoeae. Beginning with gonococcus biology and antimicrobial resistance, the volume continues with areas of study such as producing major gonococcal antigens to high purity, genetic transformation of gonococci and strategies for global RNA sequencing, evaluation of potential vaccine/drug targets and the assessment of hypothetical protein function, as well as a number of methods and protocols for studying the biological interactions of the gonococcus and the host. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Neisseria gonorrhoeae: Methods and Protocols provides researchers with a foundation for progress toward the eventual control of this disease and a significant reduction in global case numbers of gonorrhea.
Inhaltsverzeichnis zu „Neisseria gonorrhoeae “
General topic area Chapter title
1 Introduction
Introduction - biology, disease, pathogenesis
2
Infection and AMR
Algorithms for predicting infection in women
3
Antimicrobial resistance
4
Whole-genome sequencing to predict antibiotic MICs for Ngo
5
?Developing new antimicrobials to gonococci (computer-based? Etc...)
6 Genetics
Genetic transformation of Neisseria gonorrhoeae
7
Transcriptomics for Gc infection
8
RNA-seq for Neisseria gonorrhoeae
9
Biochemistry
Isolation of phenotypic variants by stereo-microscopy
10
Production of peptidoglycan
11
Protein glycosylation in Neisseria gonorrhoeae
12
?Production of purified pili/LPS
13
Vaccine
OMV preparation and characterization
14
Proteomics for vaccine development
15 Reverse vaccinology for Neisseria gonorrhoeae
16
VLP-based vaccines
17
Recombinant protein expression for gonococcal antigens
18
Biological assays
Serum bactericidal assay
19
Mouse intravaginal infection model 20
Human challenge model
21
Mouse CEACAM model of infection humanized mouse model
22
Gonococcal models of eye infection 23
Fallopian tube explant model
24
Neutrophil interactions with Neisseria gonorrhoeae
25
3D endometrial epithelial cell model
26
Rhesus macaque model of Neisseria infection
27
Methods to investigate gonococcal adhesion and invasion of human cells
28
Opsonophagocytosis of N.gonorrhoeae
Bibliographische Angaben
- 2019, 1st ed. 2019, XVII, 461 Seiten, 51 farbige Abbildungen, Maße: 18,3 x 26 cm, Gebunden, Englisch
- Herausgegeben: Myron Christodoulides
- Verlag: Springer, Berlin
- ISBN-10: 1493994956
- ISBN-13: 9781493994953
- Erscheinungsdatum: 23.05.2019
Sprache:
Englisch
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