Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries
(Sprache: Englisch)
In jüngster Zeit hat sich die Palette der Festphasenreaktionen um neue Methoden zur Kohlenhydratsynthese erweitert. Dieses Buch beschreibt Details der Fixierung von Kohlenhydraten an gekörnten Trägern, u.a. Kopplung und Screening sowie Strategien zur...
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Produktinformationen zu „Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries “
In jüngster Zeit hat sich die Palette der Festphasenreaktionen um neue Methoden zur Kohlenhydratsynthese erweitert. Dieses Buch beschreibt Details der Fixierung von Kohlenhydraten an gekörnten Trägern, u.a. Kopplung und Screening sowie Strategien zur Herauslösung des Reaktionsprodukts. Mit Beiträgen führender Kohlenhydratchemiker!
Klappentext zu „Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries “
Thorough coverage of recent developments in the field of solid support oligosaccharide synthesisSolid-phase synthesis of carbohydrates presents unique challenges to synthetic chemists and currently represents one of the hottest areas of research in bioorganic chemistry. Solid Support Oligosaccharide Synthesis and Combinatorial
Carbohydrate Libraries addresses the exciting expectation that solid-phase assembly of oligosaccharides will have a fundamental impact on the field of glycobiology. This publication details the methodologies currently investigated for the attachment of carbohydrates to beads, synthesis including coupling strategies, and removal of the product from beads.
With chapters written by eminent contributing authors, the material explores different synthetic strategies, glycosylation protocols, the use of solid supports versus soluble polymeric supports, and "on-resin" analytical methods. Tremendous progress in the field has set the stage for Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries to provide a wealth of information on such topics as:
* Specific oligosaccharide structures used in signal transduction processes
* Preparation and screening of glycopeptide libraries
* Solid-phase carbohydrate synthesis
Covering state-of-the-art developments in the field, Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries is a comprehensive resource for bioorganic and organic chemists, biochemists, and medicinal chemists.
Inhaltsverzeichnis zu „Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries “
Preface.Contributors.
Solid-Phase Carbohydrate Synthesis: The Early Work (W.-C. Haase & P. Seeberger).
The Glycal Assembly Method on Solid Supports: Synthesis of Oligosaccharides and Glycoconjugates (P. Cirillo & S. Danishefsky).
The Sulfoxide Glycosylation Method and its Application to Solid-Phase Oligosaccharide Synthesis and the Generation of Combinatorial Libraries (C. Taylor).
The Use of O-Glycosyl Trichloroacetimidates for the Polymer-Supported Synthesis of Oligosaccharides (L. Knerr & R. Schmidt).
Synthesis of Oligosaccharides on Solid Support Using Thioglycosides and Pentenyl Glycosides (V. Wittmann).
Solid-Phase Oligosaccharide Synthesis Using Glycosyl Phosphates (W.-C. Haase, et al.).
Stereoselective -Mannosylation on Polymer Support (Y. Ito & H. Ando).
Tools for "On-Bead" Monitoring and Analysis in Solid-Phase Oligosaccharide Synthesis (W.-C. Haase, et al.).
Polyethyleneglycol -Monomethylether (MPEG)-Supported Solution-Phase Synthesis of Oligosaccharides (J. Krepinsky & S. Douglas).
Two-Direction Glycosylations for the Preparation of Libraries of Oligosaccharides (G.-J. Boons & T. Zhu).
Carbohydrate Libraries in Solution Using Thioglycosides: From Multistep Synthesis to Programmable, One-Pot Synthesis (E. Simanek & C.-H. Wong).
Carbohydrate Libraries by the Random Glycosylation Approach (O. Kanie & O. Hindsgaul).
Solid-Phase Synthesis of Biologically Important Glycopeptides (N. Bézay & H. Kunz).
Preparation and Screening of Glycopeptide Libraries (P. St. Hilaire, et al.).
Index.
Autoren-Porträt
PETER H. SEEBERGER is Firmenich Assistant Professor of Chemistry at the Massachusetts Institute of Technology in Cambridge, Massachusetts.
Bibliographische Angaben
- 2001, 1. Auflage, XII, 308 Seiten, mit zahlreichen Abbildungen, Maße: 24,5 cm, Gebunden, Englisch
- Herausgegeben: Peter H. Seeberger
- Verlag: Wiley & Sons
- ISBN-10: 0471378283
- ISBN-13: 9780471378280
Sprache:
Englisch
Pressezitat
"a splendid overview over the state of the art of the field" (Perkin Transactions, No.23, 2001)"a valuable addition to the reference literature" (Synthesis, No. 5, 2002)
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