Spherical Crystallization as a New Platform for Particle Design Engineering

Introduction.- Concept of spherical crystallization.- Paradigm shifted pharmaceutical process introduced by spherical crystallization.- Particulate-design platform developed by the Advanced Spherical Crystallization System.- Development of Novel Microsphere and Microballoon DDS by Polymeric Spherical Crystallization.- Development of PLGA Nanopsphere for Drug Delivery System (DDS) Prepared by Polymeric Spherical Crystallization.- Application of PLGA NSs to cosmetics.- Future perspectives of PLGA nanospheres for advanced DDSs and continuous preparation systems for spherical crystallizers.

[Current Position and Affiliations]Contract Professor of Pharmaceutical Technology, Faculty of Science, Aichi Gakuin University, Kusumoto, Chikusaku, Nagoya 464- 8650, JapanEmeritus Professor of Gifu Pharmaceutical University, Daigaku Nishi, Gifu 501- 1113, Japan [Fields and Areas of Specialization]Particulate design engineering for drug delivery systems including spherical crystallization,agglomeration, microencapsulation, nanocapsule [Education]1964, March B. Pharm. Nagoya City University, Japan1966, March M. Pharm. Kyoto University, Japan1970, January Ph. D. Kyoto University, Japan [Position Held]1969, April Assistant Professor, Gifu Pharmaceutical University1972-74 Postdoctoral Fellow, National Research Council of Canada1977 Invited Visiting Scientist, National Research Council of Canada1978, April Associate Professor, Gifu Pharmaceutical University1983, April Professor, Gifu Pharmaceutical University1986 Invited Visiting Professor (JSPS), National University of Singapore1991 Invited Visiting Professor, Shenyang Pharmaceutical University [Award](1) The Most Promotive Research Work Award, 1986 from Pharmaceutical Society of Japan (2) The 4th Upjohn Fellowship for Scientific Research 1990 for "Particle Design for Development of Novel Dosage Forms"(3) The Science Award, 1992 from The Academy of Pharmaceutical Science and Technology, Japan(4) The Conference Pharmaceutiques Barre 1993 from The Faculty of Pharmacy, University of Montreal (Canada)(5) The 9th Annual Colorcon Award, 1995 from FIP (International Pharmaceutical Federation) Foundation for Education and Research(6) American Association Pharmaceutical Scientist (AAPS) Fellow (Seattle, 1996)(7) The Best Paper Award, 1997 from the Academy of Pharmaceutical Science Technology, Japan(8) KONA Award, 1998 from the Hosokawa Powder Technology Foundation(9) Science Award, 2000 from Gifu News Paper Press(10) Pharmaceutical Sciences World Congress (PSWC) Research Achievement Award, 2004 (11) Swiss Galenic Pharmaceutical