Tight Junctions in Inflammation and Cancer
(Sprache: Englisch)
This book provides an updated account of tight junctions of different epithelia and endothelia and addresses their anatomy, biochemistry, physiology, synthesis, assembly, and modulation. It also discusses the relationship between molecular structure,...
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This book provides an updated account of tight junctions of different epithelia and endothelia and addresses their anatomy, biochemistry, physiology, synthesis, assembly, and modulation. It also discusses the relationship between molecular structure, function, regulation, posttranslational modifications of tight junction proteins and their role in gut microbiota maintenance, epithelial-mesenchymal transition, and intestinal barrier dysfunction-associated disorders important for the progression of human cancers. This book presents the pathological alterations of tight junctions at the blood-brain barrier that intensify or even initiate neurological dysfunction. Further, it reviews the significance of tight junctions and tight junction proteins in cancer development, infectious diseases, allergic reactions, and autoimmune disorders. Lastly, it highlights strategies for modulating tight junctions to enhance drug availability and organ deposition. This book is immensely useful for basic, translational, clinical, and interdisciplinary cancer researchers, practicing oncologists, and immunologists.Inhaltsverzeichnis zu „Tight Junctions in Inflammation and Cancer “
Chapter 1. Inflammation and Cancer: Role of Tight Junctions.- Chapter 2. Regulation of tight junction by cadherin adhesion and its implication in inflammation and cancer.- Chapter 3. Tight junctions, epithelial-mesenchymal transition and cancer metastasis.- Chapter 4. Imaging techniques to study tight junctions.- Chapter 5. Tight junction proteins as emerging drug targets: Expanding the horizons from inflammation to cancer.- Chapter 6. Tight Junctions and signaling pathways in cancer.- Chapter 7. Molecular architecture and function of tight junctions.- Chapter 8. The role of tight junction proteins in cancer.Autoren-Porträt
Dr. Ajaz A. Bhat currently works as a staff scientist at Sidra Medicine, Qatar. He completed his Ph.D. in vaccine immunology from All India Institute of Medical Sciences, AIIMS, New Delhi, one of the premier medical institutes in India. After his Ph.D., he moved to Vanderbilt University Medical School (VUMS), Nashville, TN, USA, for a postdoctoral fellowship. During his eleven years of post-PhD training, he gained broad experience of the importance of tight junction proteins (Claudins) in intestinal homeostasis and colorectal cancer pathogenesis. In his second postdoctoral fellowship, he studied e role of bile acid induced APE1/Ref1 in the pathogenesis of esophageal cancer. Currently, his research focus is cancer metabolism, cancer imaging, cancer immunotherapy, drug resistance, Cancer Genetics, Obesity, and Diabetes.He has published his findings in reputed journals like Nature Communications, GUT, Oncogene, Cancer Research, and Molecular Cancer. He has received awards from the Immunology society and the American Association of Cancer research. Dr. Bhat was recently awarded as an outstanding researcher from Sidra Medicine. He is an active member of many Immunology and Cancer societies and serves in the editorial board and review committee of many peer-reviewed journals.
Dr. Punita Dhawan is currently working as a Professor at the Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA. Her research focuses on understanding the novel biomarkers and therapeutic targets for colorectal cancer progression and metastasis. The field of epithelial barrier physiology with specific consideration of claudin proteins was born in 1998, and in 2005 she published a ground-breaking finding that contrary to the conventional wisdom, an upregulated claudin-1 expression promotes sporadic colon cancer progression in JCI (J Clin Invest. 2005 Jul;115(7):1765-76). After that, her
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ongoing investigations to understand the molecular details of the role of this protein in the regulation of intestinal homeostasis and pathologies have resulted in publications in Gastroenterology, GUT, Cancer Research, Mucosal Biology, Oncogene, etc.. In 2015, she demonstrated the role of Claudin-7 as a tumor suppressor in colorectal cancer, and this paper has received great attention. Her studies also focus on determining the role of cancer stem cells (CSCs) in colon cancer metastasis and chemoresistance. In this course, her group has generated novel reagents, genetically modified cell lines, and multiple mouse models with specific modification of claudin-1 and claudin-7 proteins alone or in association with other significant co-founders but also established our leadership in this field of investigation. As PI or co-Investigator on federally funded grants, she laid the groundwork for the proposed research to perform these studies and have the expertise, leadership, and motivation necessary to successfully carry out the proposed work. In addition, a member of the iCaRe2 Biobank/Biorepository has access to a "state of the art" patient cohort of CRC samples. As principal investigator or co-Investigator on federal, regional, and local grant funding, including NIH-R21, R01 and VA-merit awards aimed at intestinal pathologies and cancer, she effectively demonstrates leadership as the PI of this unique PI multi-disciplinary grant proposal.
Dr. Mohammad Haris is an associate professor at the Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA. He leads the molecular and metabolic imaging research program to develop novel MR imaging methods to image and diagnose various human diseases at their incipient stage. His additional role provides interdisciplinary training projects and an educational environment on biomedical imaging to undergraduat
Dr. Mohammad Haris is an associate professor at the Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA. He leads the molecular and metabolic imaging research program to develop novel MR imaging methods to image and diagnose various human diseases at their incipient stage. His additional role provides interdisciplinary training projects and an educational environment on biomedical imaging to undergraduat
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Bibliographische Angaben
- 2023, 1st ed. 2023, XIII, 193 Seiten, Maße: 15,5 x 23,5 cm, Gebunden, Englisch
- Herausgegeben: Ajaz A. Bhat, Mohammad Haris, Muzafar A. Macha, Punita Dhawan
- Verlag: Springer, Berlin
- ISBN-10: 9819924146
- ISBN-13: 9789819924141
Sprache:
Englisch
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